Hemoglobin A (HbA) Peptide

Reconstitution Buffer: Restore with deionized water (or equivalent)

Reconstitution Volume: 50μL

Buffer: None

Stabilizer: None

Synonyms: Hbβ Control Peptide, Hemoglobin beta subunit, HBB, Sickle Cell Disease (SCD)

Background: HbA peptide correspond to the hemoglobin beta subunit wild type variant A isoform. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbA peptide can be used as a control with the HbA antibody. This peptide is ideal for investigators involved in Cardiovascular and developmental biology research.